Clinical Medicine

Read e-book online Viral Hepatitis in Children: Unique Features and PDF

By Michelle Rook, Philip Rosenthal (auth.), Maureen M. Jonas (eds.)

ISBN-10: 1607613727

ISBN-13: 9781607613725

ISBN-10: 1607613735

ISBN-13: 9781607613732

Viral Hepatitis in young children: designated gains and possibilities is a different quantity that has been created to handle the specified issues relating to viral hepatitis in teenagers. It contains the most recent details and proposals particularly directed on the pediatric inhabitants, and highlights the information gaps in order to must be crammed to enhance our realizing of those infections and therapy of this precise staff. skilled practitioners from all over the world have contributed those reports, incorporating the newest stories, the present concepts, and the designated pediatric concerns that form medical care. This fabric will be certain the study schedule for this box going ahead. Viral Hepatitis in kids: distinct positive aspects and possibilities is a precious source for pediatricians, pediatric gastroenterologists, hepatologists and infectious sickness experts that deal with young ones with viral hepatitis.

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Additional resources for Viral Hepatitis in Children: Unique Features and Opportunities

Example text

Chronic HBV infection was a relative contraindication to liver transplantation in the 1970s and 1980s, but the demonstration in the 1990s that administration of Hepatitis B immune globulin (HBIG) is efficacious in decreasing infection of the allograft has allowed successful transplantation with control of re-infection. Success rates were further improved by the addition of lamivudine, so that the ­outcome of liver transplantation for chronic hepatitis B is now comparable to that for other etiologies in adults [64].

Twenty-three children, all infected in the first year of life, HBeAg positive, and with normal aminotransferases, were treated with lamivudine alone for 8 weeks followed by lamivudine plus IFN-a 5 MU/m2 three times weekly for 10 months. Of the 23, 5 seroconverted to anti-HBe and 4 of these 5 became HBsAg negative and HBsAb positive. No child developed a YMDD mutant and most (78%) became HBV DNA negative. A side effect of treatment was decrease in weight and linear growth rate, and this remained significant for height 12 months after the end of treatment [43].

Hepatitis B control in Europe by universal vaccination programmes: the situation in 2001. J Med Virol. 2002;67:433–439. 22. Stroffolini T, Mele A, Tosti ME, et al. The impact of the hepatitis B mass immunisation campaign on the incidence and risk factors of acute hepatitis B in Italy. J Hepatol. 2000; 33:980–985. 23. Merican I, Guan R, Amarapuka D, et al. Chronic hepatitis B virus infection in Asian countries. J Gastroenterol Hepatol. 2000;15:1356–1361. 24. Hsu HY, Chang MH, Chen DS, Lee CY, Sung JL.

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Viral Hepatitis in Children: Unique Features and Opportunities by Michelle Rook, Philip Rosenthal (auth.), Maureen M. Jonas (eds.)


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