By Ferid Murad, Gerald D. Aurbach (auth.), Norbert Freinkel M. D. (eds.)
In the phrases of Disraeli, "To be awake that you're unaware of the proof is a smart step to wisdom. " for many people, the awake expertise of relative lack of knowledge is an uncomfortable element of everyday life. New info look in such inexorable great quantity that the need for non-stop retooling has joined loss of life and taxes as an inescapable part of our destinies. probably it's this "consciousness of lack of expertise" that bills for the luck of the previous volumes of this new sequence. The yr in Metabolism and The yr in Endocrinology sequence have been brought with the avowed purpose of "providing a good and relaxing bridge among those people who are developing new wisdom on the bedside and the pro attention of these for whom such wisdom is finally meant. " That goal turns out fairly acceptable at a time while the award of the 1977 Nobel Prize in medication or body structure to Guillemin, Schally, and Yalow has served to stress the epoch-making advances that experience characterised the new process endocrinology and me~bolism. For the 1977 quantity of The 12 months in Metabolism, the former formulation has been preserved. an identical across the world well-known specialists back have contributed commentaries in regards to the development of their components of craftsmanship. they've been joined via Drs. Jack W. Coburn, David L. Hartenbower, and Charles R. Kleeman, who've supplied a brand new part on Divalent Ion Metabolism.
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Extra resources for The Year in Metabolism 1977
Neer, E. , 1976, The size of adenylate cyclase and guanylate cyclase from the rat renal medulla, J. Supramo!. Struct. 4:51. Neethling, A. , and Shanley, B. , 1976, Cyclic GMP excretion and hepatoma, Lancet 2:578. , and Perlman, R. , 1972, Regulation of gene transcription in E. coli of cyclic AMP, Adv. Cyclic Nucleotide Res. 1: 11. Pastan, I. , Johnson, G. , and Anderson, W. , 1975, Role of cyclic nucleotides in growth control, Annu. Rev. Biochem. 44:491. Pointer, R. , Butcher, F. , and Fain, J.
4 / " ..... ,.. .. r---T--_ .... ','" ,.... ) 2 2 4 6 8 10 I ... , 12 /1 I ~' . ,I 14 16 18 Age Fig. 4. Ratio of cAMP to cGMP excreted daily in urine in normal children and those with cystic fibrosis. E. for the age groups designated. Asterisks designate values that are significantly different from normals. From Murad et a/. (1975b). 2. , 1975b). This is best illustrated by the ratio of cAMP to cGMP excreted in normal children and those with cystic fibrosis (Fig. 4). The significance of these observations is not known.
Bhoola, K. , Harvey, R. , and Heap, R. , 1976, Stimulation-secretion coupling in the pancreas: role of cyclic GMP in modulating enzyme secretion produced by acetylcholine and cholecystokinin-pancreozymin, J. Biol. 258:87. Anderson, N. , and Ramwell, P. , 1974, Biological aspects of prostaglandins, Arch. Intern. Med. 133:30. Appleman, M. , and Terasaki, W. , 1975, Regulation of cyclic nucleotide phosphodiesterase, Adv. Cyclic Nucleotide Res. 5: 153. Appleman, M. , and Torres, H. , 1966, Factors affecting the activity of muscle glycogen synthetase.
The Year in Metabolism 1977 by Ferid Murad, Gerald D. Aurbach (auth.), Norbert Freinkel M. D. (eds.)