By Focko F. G. Rommerts (auth.), Prof. Dr. med. Eberhard Nieschlag, Priv.-Doz. Dr. med. Hermann M. Behre (eds.)
New advancements in testosterone motion and treatment are summarized right here through the world over well known specialists. They overview either simple and medical wisdom in 20 chapters. This 2d version has been completely revised and prolonged. The publication provides the biochemistry of testosterone, its biosynthesis, metabolism and mechanisms of motion in aim organs. results on bones, muscular tissues, lipids, hair, the prostate, and the mind are thought of in separate chapters. Syndromes because of androgen resistance are defined so that it will spotlight the significance of appropriately functioning enzymes and receptors within the goal organs. The pharmacology, pharmacokinetics and scientific makes use of and abuses of testosterone arrangements are mentioned intimately, and unwanted effects of testosterone remedy are reviewed. this is often the state of the art booklet approximately testosterone motion and remedy for endocrinologists, andrologists, urologists and pharmacologists.
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Additional resources for Testosterone: Action - Deficiency - Substitution
1995), when he proposed that membrane transduction pathways, activated by growth factors which interact with the nuclear receptor via intracellular phosphorylation cascades, may "set the nuclear receptor thermostat" for responses to steroids. In a similar fashion the signal transduction pathways activated by the membrane effects of steroids could also influence its genomic actions, indicating that nuclear and membrane effects of steroids are probably more closely linked than previously thought (see Fig.
4 Molecular pathophysiology . . . . . . . . . . . . 82. . 5 Clinical management . . . . . . . . . . . . ... 83. . . 3 Prostate cancer .... .. .. . . . . .... . . . . 9 Key messages ... . . . . .... . . . . . . . . . 10 References . . . .. . . . ... . . . . . . . 1 Introduction The androgen receptor (AR 1) is a member of the steroid receptor family of nuclear transcription factors, whose action requires the binding of ligand.
Developmental pathophysiology ... . . . . . . ... Endocrine findings . . . . . . . . . . . . . . . . . . . . . . . .. Androgen binding studies . . . Genetic basis . . . . . . . . . . . . . . . Molecular pathophysiology . . . . . . . . . . . . Is there a genotype/phenotype correlation for AR mutations? . Carrier detection and prenatal diagnosis . .. . . .. Clinical management . . ... .. . . . . . .
Testosterone: Action - Deficiency - Substitution by Focko F. G. Rommerts (auth.), Prof. Dr. med. Eberhard Nieschlag, Priv.-Doz. Dr. med. Hermann M. Behre (eds.)