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Potential Carcinogenic Hazards from Drugs: Evaluation of by R. M. Taylor M.D. (auth.), René Truhaut (eds.) PDF

By R. M. Taylor M.D. (auth.), René Truhaut (eds.)

ISBN-10: 3642878989

ISBN-13: 9783642878985

ISBN-10: 3642879004

ISBN-13: 9783642879005

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La reponse a cette question est tres delicate, en raison de la longueur et du cout eleve des experimentations necessaires pour reveler la potentialite cancerogene, avec, en plus, les difficultes frequentes d'interpretation que nous avons soulignees. Des exigences trop severes risquent en effet de decourager la recherche therapeutique dans l'industrie, d'autant que les drogues, dont la fabrication et la commercialisation est envisagee, sont loin de connaitre toutes Ie succes et, pour la grande majorite d'entre elles, sont meme destinees a etre abandonnees.

With the present methods of investigation, it is questionable, for instance, if differences between the thymic atrophy caused by a carcinogenic polycyclic hydrocarbon or by urethan and that caused by cortisone can be ascertained, although the former compounds will induce a high percentage of thymic lymphosarcomas, and the latter will not; the same consideration applies to the thymic repair and hyperplasia which follow atrophy. However, the study of the kinetics of these changes, may be rewarding (FIORE-DONATI and KAYE, 1964).

No 6, 53-57 (1956). FITZHUGH, O. , and NELSON, A. , Comparison of the chronic toxicity of triethylene glycol with that of diethylene glycol. J. industr. Hyg. 28, 40-43 (1946). - - Comparison of the chronic toxicities of synthetic sweetening agents. Fed. Proc. 9, 272 (1950). , The specific mutagenic effect of base analogues on phage T 4, J. molec. BioI. 1, 87-105 (1959). - The difference between spontaneous and base-analogue induced mutations of phage T 4; Proc. nat. Acad. Sci. ) 45, 622633 (1959).

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Potential Carcinogenic Hazards from Drugs: Evaluation of Risks by R. M. Taylor M.D. (auth.), René Truhaut (eds.)


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