By Raphael M. Ottenbrite, Kristine Kuus, Alan M. Kaplan (auth.), Emo Chiellini, Paolo Giusti (eds.)
This publication includes the accrued papers awarded on the Inter nationwide Symposium on Polymers in drugs, Biomedical and Pharma cological purposes, which was once held at Porto Cervo, Italy, may well 24-28, 1982. To the easiest of our wisdom, this symposium was once the 1st to be equipped in Italy solely dedicated to different facets of using man made and semisynthetic macromolecular fabrics within the box of biomedical and pharmacological functions. The inten~ tion of the Organizing Committee of the symposium used to be the advertising of a systematic and cultural initiative to realize the eye of assorted specialists in line study of the possibility of certainly de signed "man-made" polymeric fabrics in biomedical functions. With hugely certified and world wide attendance, the above aim was once absolutely happy. certainly the possibility of assembly to gether in a good conceived and discreet nook of the area, scien tists with assorted cultural backgrounds and targets helped ex have a tendency the that means of the symposium some distance past the Italian borders and the views of the nationwide study Council of Italy (CNR) , the main sponsor of the meeting.
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Extra info for Polymers in Medicine: Biomedical and Pharmacological Applications
K. Pratt en , R. Duncan, H. C. Cable, R. Schhe, H. Ringsdorf and J. B. Lloyd, Chem. BioI. Inter. 35:319 (1981). 36. M. K. Pratten and J. B. Lloyd, Biochem. ~. 180:567 (1979). 37. T. Koolstra, M. K. Pratten and J. B. Lloyd, Bioscience Repts. 1:587 (1981). 38. M. K. Pratten, P. C. Millard and J. B. Lloyd, Mioscience Repts. 1:125 (1981). 39. M. L. Karngusky and J. K. Lazdins, ~. Immunol. 121:809 (1978). 40. I. Carr, Clin. Invest. Med. 1:59 (1978). 41. P. S. Morahan, P. J. Edelson and K. Gass, ~. Immunol.
8: Principle of recognition of sugar-containing liposomes by Con A. -Me ~1anp) is added (14). Although only first attempts have been made, and though the hypothetic concept of polymeric antitumour agents on a cellular level is far from being realized, it seems worth while to further investigate the potential of polymeric liposomes and to try to get closer to the structures of which they are a simple model: to cells (Fig. 9). 31 ANTITUMOUR AGENTS ON MOLECULAR AND CELLULAR LEVEL? A,b", + I I I ;41", " I I \ I \ I Fig.
3 mg/kg Day 7 Day 14 Day 20 Day 28 Day 34 Day 42 100 100 590 5,643 348 5,040 386 3,340 225 2,063 187 2,162 113 780 100 6,589 3,904 1,884 1,132 839 721 Numbers represent the amount of radioactivity in the immune prec~p~ tate obtained from sera at the indicated time, normalized to the amount of radioactivity present in the precipitate from the pretreatment sera. Table 6. 0 Interferon titer (mean reference units/ml~) 15 15 198 1,940 4,473 5,820 b (0-25)(0-25) (25-250) (200-5,000) (600-15 ,000) (2,000-10,143) ~Assay was done in HSF4 cells, using vesicular stomatitis virus as challenge and cytopathic effect as endpoint (international reference gnits); 8 hour sample following first dose; £ 3 trials at each level.
Polymers in Medicine: Biomedical and Pharmacological Applications by Raphael M. Ottenbrite, Kristine Kuus, Alan M. Kaplan (auth.), Emo Chiellini, Paolo Giusti (eds.)