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M. G. Sevag's Origins of Resistance to Toxic Agents PDF

By M. G. Sevag

ISBN-10: 0123956595

ISBN-13: 9780123956590

ISBN-10: 0323148328

ISBN-13: 9780323148320

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Proc. 1954, 51. Valentine, F . C. , and Shooter, R. A. "Recent Advances in Chemotherapy," Vol. 3, Antibiotics. J . and A. Churchill, Ltd. London, 1954. Witkin, Ε . M. (1947). Genetics 32, 221. Witkin, Ε . M. (1950). Methods Med. Research 3, 23. Zinder, N. , and Lederberg, J . (1952). /. Bacteriol. 64, 679. M E C H A N I S M OF RESISTANCE TO PROFLAVINE B A C T E R I U M LACTIS (Aerobacter IN AEROGENES aerogenes) A. C . R . DEAN* Physical Chemistry Laboratory, University of Oxford, Oxford, England I.

C. COMPOSITE CHANGES Fig. 3 illustrates one of many possible composite situations in the development of resistance. All sensitive cells ( S ) are killed by action of the drug. However, among these sensitive individuals several inducible mutants may be present. These inducible cells may now respond adaptively and become resistant following exposure to drug action, by mechanisms illustrated in Fig. 2. Returning again to the production of penicillinase, this faculty must be under genetic control since it arises in only a few of the possible types of mutants resistant to penicillin.

Lederberg, J . , and Lederberg, Ε . M. (1952). J . Bacteriol. 63, 399. Luria, S. , and Delbrück, Μ. (1943). Genetics 28, 491. , and Rowley, D. ( 1 9 5 3 ) . /. Gen Microbiol 9, 226. Mitchison, D. , ( 1 9 5 3 ) . Symposia Soc. Gen. Microbiol. (London) 3, 253. Newcombe, Η. B. ( 1 9 4 9 ) . Nature 164, 150. Newcombe, Η. , and Nyholm, Μ. H. ( 1 9 5 0 ) . Genetics 35, 603. Pollock, M. R. ( 1 9 5 3 ) . Symposia Soc. Gen. Microbiol (London) 3, 150. Romansky, M. J . , Fusillo, Μ. , and Kuhns, D. M. (1953).

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Origins of Resistance to Toxic Agents by M. G. Sevag

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