By Wolfgang Drexler, James G. Fujimoto
Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is a strong imaging method that allows non-invasive, in vivo, excessive solution, cross-sectional imaging in organic tissue. among 30 to forty Million OCT imaging strategies are played consistent with 12 months in ophthalmology. the general industry is expected at greater than half Billion USD.
A new iteration OCT know-how used to be built, dramatically expanding answer and velocity, reaching in vivo optical biopsy, i.e. the visualization of tissue architectural morphology in situ and in actual time. sensible extensions of OCT know-how allow non-invasive, intensity resolved useful evaluation and imaging of tissue.
The ebook introduces OCT expertise and functions not just from an optical and technological point of view, but additionally from the biomedical and medical standpoint. This moment version is extensively prolonged and covers considerably extra issues then the 1st version of this publication. The chapters are written via top foreign examine teams, in a method understandable to a vast viewers. it will likely be of curiosity not just to physicists, scientists and engineers, but in addition to biomedical and scientific researchers from various scientific specialties.
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Extra info for Optical Coherence Tomography: Technology and Applications
Sufficient numbers of patients having a given pathology must be investigated in order to ensure that the sample size is large enough to generate statistically significant results. Because many types of dysplasia or cancer have a low incidence, patient enrollments may be large. For these reasons, the investigation and development of OCT for cancer diagnosis remains a challenging and ongoing area of research. Part 2 of this book, Optical Coherence Tomography Applications, includes several chapters which survey a broad range of OCT applications, including the detection of early neoplastic changes in different organ systems.
OCT technology was transferred to industry by our group at MIT and introduced commercially for ophthalmic diagnostics in 1996 (Carl Zeiss Meditec). Early instruments had an axial resolution of 10 um and an imaging speed of 100 A-scans/s. G. Fujimoto and W. Drexler A-Scan Value 1 S Mirror Image N T Caliper ON Log Reflection I Microns 600 210° Thickness Chart 500 400 300 200 100 0 0 100 200 300 400 500 A-Scan 253 286 259 288 218 272 224 283 229 Microns 0 100 200 300 400 500 μm Fig. 15 OCT topographic map of retinal thickness.
Since interferometry measures the field rather than the intensity, it is equivalent to heterodyne detection in optical communication. Weak signals Es(t) are multiplied by a strong reference field Er(t) to produce heterodyne gain and very high, shot noise-limited sensitivities can be achieved. In addition, since the intensity is the square of the field, very high dynamic ranges are possible. 1 Early OCT Technology and Systems Optical coherence tomography imaging was demonstrated in 1991 by Huang et al.
Optical Coherence Tomography: Technology and Applications by Wolfgang Drexler, James G. Fujimoto