By D. Schiffer (auth.), P. Paoletti, K. Takakura, M. D. Walker, G. Butti, S. Pezzotta (eds.)
This quantity includes the lawsuits of the newest in a sequence of foreign symposia on advances in neuro-oncology, held September 26-29, 1990, in San Remo, Italy and backed via the collage of Pavia, I.R.C.C.S. Policlinico San Matteo (Pavia, Italy) and the Giovanni Lorenzini scientific beginning (Milan-Houston). It drew papers from six continents of the realm, was once attended through over 500 investigators, and validated the intense power, intensity and breadth of analysis which characterizes modem neuro-oncology. Over the process the decade, there was a impressive shift in learn conducted within the heterogeneous box of neuro-oncology, which seems to be clear of medical descriptive reviews, and towards extra easy and primary research of the pathology, immunohis tochemistry, biochemical and mobile subsets of mind tumors. in addition to the conventional fields of neurology, neurosurgery, neuropathology, and radiation remedy, there was an elevated curiosity and involvement via investigators within the fields of clinical oncology, neuroradiology, immunology, and plenty of components of primary neurobiology. It has turn into obvious that curiosity has additionally been exhibited in a broader spectrum of tumors than simply the malignant glial sequence, and reviews in meningioma, craniopharyngioma, neurinomas, and the pituitary tumors have been pronounced. a number of periods have been dedicated to the distinct difficulties of pediatric mind tumors.
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N. Engl. J. Med. 313: 1111-1116, 1985. 33. : Isolation, karyotype and clonal growth of heterogeneus subpopolations of human malignant gliomas. Cancer Res. 41: 2349-2359,1981. 34. y on endothelial cells. Cancer 62: 2139-2144, 1988. 35. SMITH R.. : Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors. EMBO J. 7: 1013-1022, 1988. 36. : C-DNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.
References sa Bigner Mark 1, Bigner DD (1990) Cytogenetics of human brain tumors. Cancer Genet Cytogenet47;141-154. Birchmeier C, Sharma S, Wigler M (1987) Expression and rearrangement of the ROSI gene in human glioblastoma cells. Proc Natl Acad Sci VSA 84:9270-9274 Black P, Maxwell M, Antoniades Schoene W, Morris 1 (1989) Expression of PooF-related genes in human astrocytomas. 1 Neurooncol7 Suppl:Sl9 (abstract) Bravo R, Frank R, Blundell PA, MacDonald-Bravo H (1987) Cyclin/PCNA is the auxiliary protein of DNA polymerase alpha.
Protocol-2 is a monolayer culture system that treats the heterogeneous population (sensitive and resistant cells) with repeated and increasing concentrations of BCNU [9). If both protocols produced karyotypically similar cells, then the culture technique could be eliminated as a means of selecting for the non-random karyotypic deviation associated with the drug selection process. 23 Results and Discussion cytogenetic analyses of the BCNU-resistant clonal cells (protocol-I) and monolayer culture cells (protocol-2) demonstrated that BCNU-resistant cells from both protocols had a specific karyotypic deviation.
Neuro-Oncology by D. Schiffer (auth.), P. Paoletti, K. Takakura, M. D. Walker, G. Butti, S. Pezzotta (eds.)