Neurology

Lawrence M. Samkoff, Andrew D. Goodman's Multiple Sclerosis and CNS Inflammatory Disorders PDF

By Lawrence M. Samkoff, Andrew D. Goodman

ISBN-10: 0470673885

ISBN-13: 9780470673881

Multiple Sclerosis and CNS Inflammatory Disorders is a pragmatic consultant to potent care of sufferers with a number of sclerosis and different neuroimmunologic and CNS inflammatory disorders.

It presents the medical foundation of a number of sclerosis together with etiology, epidemiology, and pathogenesis. It covers the diagnostic approach, the process the ailment and analysis, and using MRI in prognosis and ailment tracking. Disease-modifying  remedy algorithms for relapsing-remitting a number of sclerosis, switching treatment, and innovative a number of sclerosis remedy algorithms are all mentioned intimately. It additionally addresses a number of sclerosis in youth and being pregnant and contains overview of different therapies.

This new addition to the Neurology in perform sequence comprises sensible tips and studying features:

• Algorithms and guidelines

• “Tips and methods” bins on bettering outcomes

• “Caution” caution bins to averting problems

• “Science Revisited”—quick reminders of the elemental technological know-how ideas precious for understanding

Multiple Sclerosis and CNS Inflammatory Disorders is a perfect reference for neurologists in perform and training.

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Additional info for Multiple Sclerosis and CNS Inflammatory Disorders

Sample text

The receptor for IL-2 is CD25, the target of the monoclonal antibody daclizumab, which has shown promising early results in studies of relapsing MS. TNF-α is another proinflammatory cytokine that may play a role in MS pathogenesis. Numerous studies have reported elevation of TNF-α in CSF and in serum and of TNF-αsecreting blood mononuclear cells in MS patients compared to controls. Because of its potent proinflammatory proprieties, it was hypothesized that TNF-α would be detrimental to patients with MS, but strikingly, drugs that block TNF-α actually lead to worsening of MS.

Magliozzi, R. et al. (2006) Dendritic cells in multiple sclerosis lesions: ­maturation stage, myelin uptake, and interaction with proliferating T cells. Journal of Neuro­ pathology and Experimental Neurology, 65 (2), 124–141. Sospedra, M. & Martin, R. (2005) Immunology of multiple sclerosis. Annual Review of Immunology, 23, 683–747. L. et al. (1998) The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunological Reviews, 164, 63–72. , Piaton, G. & Lubetzki, C.

MS attacks usually occur in individuals between ages 15 and 50. The onset of symptoms is subacute over several hours to days. Symptoms then typically plateau, although they may persist for weeks to months before improving. Symptoms must persist for at least 24 h to be considered an attack consistent with MS. An attack may consist of one main clinical symptom or multiple symptoms. Occasionally, the development of symptoms will represent a pseudoexacerbation rather than a new lesion. Pseudoexacerbations may be incited by infections, such as a UTI, or by overexertion.

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Multiple Sclerosis and CNS Inflammatory Disorders by Lawrence M. Samkoff, Andrew D. Goodman


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