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By Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl

ISBN-10: 3319117181

ISBN-13: 9783319117188

ISBN-10: 331911719X

ISBN-13: 9783319117195

In 2009 the collage medication Greifswald introduced the “Greifswald method of Individualized drugs” (GANI_MED) to enforce biomarker-based individualized diagnostic and healing techniques in medical settings. Individualized drugs (IM) has led not just to controversies approximately its potentials, but additionally approximately its societal, moral and overall healthiness financial implications. This anthology focusses on those components and contains – subsequent to medical examples illustrating how the built-in research of biomarkers results in major development of healing results for a subgroup of sufferers – chapters concerning the definition, background and epistemology of IM. also there's a specialise in conceptual philosophical questions in addition to demanding situations for utilized examine ethics (informed consent approach, the IT-based consent administration and the dealing with of incidental findings). eventually it will pay cognizance to health and wellbeing financial facets. the chances of IM to begin a paradigm shift within the German overall healthiness care provision are investigated. in addition, it truly is requested even if the G-DRG process is prepared for the implementation of such ways into scientific routine.

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3 was the genus problem. To which class of phenomena—we asked—belong IM/PM according to certain definitions? It was noticed that beside many loose and therefore not clear definitions, there are two scientifically valid suggestions: on the one hand, the IM and PM terms aim at activities which can be summarized under the generic term “health care”. On the other hand, the IM and PM terms open up a category under the generic term “medical line of research”. If one asks, whether one of the two alternatives should be preferred or if a synthesis of both is desirable, it must be noticed, that by clarifying the genus questions, only half of the demands of the Aristotelian concept of definition will have been met.

Thus, different surgeries, for instance, which use the same protocol, represent the same health care practice. 10. The general expression “therapy” was chosen in the definition above on purpose. In particular, it should be avoided to only speak restrictively of drugs. On the one hand, not all therapies are based on medication, on the other hand— as shown in the example of immunoadsorption as a novel therapy option for patients with dilated cardiomyopathy (Ameling et al. 2013; Felix and Staudt 2008; Herda et al.

Html. Accessed 27 June 2014 Grabe HJ, Assel H, Bahls T et al (2014) Cohort profile: Greifswald approach to individualized medicine (GANI_MED). J Transl Med 12:144 Hasler-Strub U (2009) Aktuelle Therapien beim metastasierten Brustkrebs. Eine Übersicht über evidenzbasierte Optionen. Schweizer Zeitschrift für Onkologie 5:20–22 Herda LR, Trimpert C, Nauke U et al (2010) Effects of immunoadsorption and subsequent immunoglobulin G substitution on cardiopulmonary exercise capacity in patients with dilated cardiomyopathy.

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Individualized Medicine: Ethical, Economical and Historical Perspectives by Tobias Fischer, Martin Langanke, Paul Marschall, Susanne Michl


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