By Carolina M. Maier, Gary K. Steinberg
A complete evaluate of the medical and medical stories that experience ended in the resurgence of curiosity in hypothermia as a neuroprotective process within the therapy of stroke and annoying mind harm. subject matters of distinct value comprise intraoperative and extensive care administration of hypothermia-treated sufferers, a severe examine the opportunity of combining hypothermia with pharmacotherapy, and an replace at the most up-to-date technological advances that experience made hypothermic remedy attainable in ultra-modern medical surroundings.
Read or Download Hypothermia and cerebral ischemia : mechanisms and clinical applications PDF
Similar neurology books
Amyotrophic Lateral Sclerosis provides the main entire, clinically-focused info on ALS (Lou Gehrig's disorder) in print. the 3 authors, well known for his or her paintings during this quarter, offer cohesive and balanced assurance of this syndrome, together with the historical past, medical positive aspects, pathology and pathogenesis, remedy and administration of ALS.
This ground-breaking name offers an interdisciplinary advent to the topic of Dependability and the way it applies in drugs quite often and in neurology specifically. Dependability is the time period utilized in engineering and to a carrier that's secure, trustworthy and reliable. liable structures use a number of how to bring right carrier within the face of uncertainty caused by deceptive, faulty info, and glitches.
- Practicing Neurology: What You Need to Know 2nd Edition (Current Clinical Neurology)
- The Neurological Manifestations of Pediatric Infectious Diseases and Immunodeficiency Syndromes (Infectious Disease)
- The Innate Mind: Structure and Contents
- Neuropathic Pain
- Preventive Pharmacotherapy of Headache Disorders
Additional info for Hypothermia and cerebral ischemia : mechanisms and clinical applications
D. (1998) The influence of delayed postischemic hyperthermia following transient focal ischemia: alterations of gene expression. J. Neurol. Sci. 159, 1–10. 60. Mellergard P. and Nordstrom C. H. (1991) Intracerebral temperature in neurosurgical patients. Neurosurgery 28, 709–713. 61. Cook D. , Orszulak T. , Daly R. , and Buda D. A. (1996) Cerebral hyperthermia during cardiopulmonary bypass in adults. J. Thorac. Cardiovasc. Surg. 111, 268–269. Chapter 2 / Hypo- and Hyperthermia in Global Cerebral Ischemia 35 62.
Smith et al. ) and emphasized the need for independent control of both rectal and cranial temperatures. To study this problem carefully, we conducted experiments in which anesthetized Wistar rats received a 20-min global forebrain ischemic insult by a modification of the four-vessel occlusion method (23). Brain temperature was monitored by a thermocouple inserted stereotaxically into the striatum, and striatal temperature was regulated by a high-intensity lamp positioned over the head (21).
Lipid peroxidases, proteases, phospholipases), increasing intracellular free fatty acids and furthering free radical formation. Caspase, translocase, and endonuclease activity results in DNA fragmentation. What ensues is rapid, necrotic cell death in the ischemic core. In the ischemic penumbra, however, apoptosis (an energy-dependent programmed cell death) likely predominates over necrosis (14). All of these processes result in disintegration of the cell and stimulation of the immune system. Inflammatory and immunological responses also contribute to the pathogenesis of cerebral ischemia.
Hypothermia and cerebral ischemia : mechanisms and clinical applications by Carolina M. Maier, Gary K. Steinberg