Download PDF by Carolina M. Maier, Gary K. Steinberg: Hypothermia and cerebral ischemia : mechanisms and clinical

By Carolina M. Maier, Gary K. Steinberg

ISBN-10: 089603660X

ISBN-13: 9780896036604

ISBN-10: 1592596533

ISBN-13: 9781592596539

A complete evaluate of the medical and medical stories that experience ended in the resurgence of curiosity in hypothermia as a neuroprotective process within the therapy of stroke and annoying mind harm. subject matters of distinct value comprise intraoperative and extensive care administration of hypothermia-treated sufferers, a severe examine the opportunity of combining hypothermia with pharmacotherapy, and an replace at the most up-to-date technological advances that experience made hypothermic remedy attainable in ultra-modern medical surroundings.

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Additional info for Hypothermia and cerebral ischemia : mechanisms and clinical applications

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D. (1998) The influence of delayed postischemic hyperthermia following transient focal ischemia: alterations of gene expression. J. Neurol. Sci. 159, 1–10. 60. Mellergard P. and Nordstrom C. H. (1991) Intracerebral temperature in neurosurgical patients. Neurosurgery 28, 709–713. 61. Cook D. , Orszulak T. , Daly R. , and Buda D. A. (1996) Cerebral hyperthermia during cardiopulmonary bypass in adults. J. Thorac. Cardiovasc. Surg. 111, 268–269. Chapter 2 / Hypo- and Hyperthermia in Global Cerebral Ischemia 35 62.

Smith et al. [22]) and emphasized the need for independent control of both rectal and cranial temperatures. To study this problem carefully, we conducted experiments in which anesthetized Wistar rats received a 20-min global forebrain ischemic insult by a modification of the four-vessel occlusion method (23). Brain temperature was monitored by a thermocouple inserted stereotaxically into the striatum, and striatal temperature was regulated by a high-intensity lamp positioned over the head (21).

Lipid peroxidases, proteases, phospholipases), increasing intracellular free fatty acids and furthering free radical formation. Caspase, translocase, and endonuclease activity results in DNA fragmentation. What ensues is rapid, necrotic cell death in the ischemic core. In the ischemic penumbra, however, apoptosis (an energy-dependent programmed cell death) likely predominates over necrosis (14). All of these processes result in disintegration of the cell and stimulation of the immune system. Inflammatory and immunological responses also contribute to the pathogenesis of cerebral ischemia.

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Hypothermia and cerebral ischemia : mechanisms and clinical applications by Carolina M. Maier, Gary K. Steinberg

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