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Handbook of Neurochemistry and Molecular Neurobiology: - download pdf or read online

By H. Wolburg, A. Lippoldt, K. Ebnet (auth.), Abel Lajtha, Maarten E. A. Reith Ph.D. (eds.)

ISBN-10: 0387303472

ISBN-13: 9780387303475

ISBN-10: 0387303804

ISBN-13: 9780387303802

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Extra info for Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport

Example text

4 Use of In Vitro BBB Models . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . BBB in Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Hypoxia and Reoxygenation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Infections . . . . .

Proc Natl Acad Sci USA 96: 511-516. Morita K, Sasaki H, Furuse M, Tsukita S. 1999b. Endothelial claudin: Claudin‐5/TMVCF constitutes tight junction strands in endothelial cells. J cell Biol 147: 185-194. Muir AR, Peters A. 1962. Quintuple‐layered membrane junctions at therminal bars between endothelial cells. J Cell Biol 12: 443-448. Muller WA. 2003. Leukocyte‐endothelial‐cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol 24: 327-334. Nagai‐Tamai Y, Mizuno K, Hirose T, Suzuki A, Ohno S.

1997). Ka´sa et al. (1991) found a similar induction of TEER by fetal human astroglia in human brain endothelial cell monolayers. , 2003) astrocytes induce better TJ integrity than normal cells do; however, the validity of the BBB models used in these experiments was not confirmed by TEER or Pe measurements. Microglia, present in primary mixed glial cultures, can also influence brain endothelial cells in cocultures. , 1998). , 2003). , 2005). Glial cell lines are also used in coculture studies, the rat C6 glioma is the most popular.

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Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport by H. Wolburg, A. Lippoldt, K. Ebnet (auth.), Abel Lajtha, Maarten E. A. Reith Ph.D. (eds.)


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