By Kimber Jest
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Additional resources for Clinical Toxicology - Vol 48, issue 6, July 2010
48 no. 6 2010 508 45. Ghio AJ, Kennedy TP, Hatch GE, Tepper JS. Reduction of neutrophil influx diminishes lung injury and mortality following phosgene inhalation. J Appl Physiol 1991; 71:657–665. 46. Kennedy TP, Rao NV, Noah W, Michael JR, Jafri MH, Gurtner GH, Hoidal JR. Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J Clin Invest 1990; 86:1565–1573. 47. Matute-Bello G, Frevert CW, Martin TR. Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2008; 295:L379–L399.
34. Glass D, McClanahan M, Koller L, Adeshina F. Provisional advisory levels (PALs) for phosgene (CG). Inhal Toxicol 2009; 21(Suppl 3):73–94. 35. Ghio A, Lehmann J, Winsett D, Richards J, Costa D. Colchicine decreases airway hyperreactivity after phosgene exposure. Inhal Toxicol 2005; 17:277–285. 36. Sciuto AM, Moran TS. Effect of dietary treatment with n-propyl gallate or vitamin E on the survival of mice exposed to phosgene. J Appl Toxicol 2001; 21:33–39. 37. Sciuto AM. Posttreatment with ETYA protects against phosgeneinduced lung injury by amplifying the glutathione to lipid peroxidation ratio.
Radiolabeling A-KG with Tc-99m In a sterile vial, A-KG was dissolved in distilled water, followed by the addition of sodium bicarbonate and gentisic acid. The contents were dissolved by gentle shaking. 0. After an incubation with 74 Mega Becquerel (MBq), Tc-99m pertechnetate for a period of 20 min at room temperature (approx. 5, v/v) as mobile phases. The radioactive contaminants were identified as reduced/hydrolyzed (R/H) Tc-99m and free Tc-99m pertechnetate. Stability studies of radiolabeled drug Stability of 99mTc-A-KG was carried out by mixing normal human serum with 99mTc-A-KG and incubating the contents at 37°C.
Clinical Toxicology - Vol 48, issue 6, July 2010 by Kimber Jest