By Hiroshi Mitsumoto MD
Amyotrophic Lateral Sclerosis offers the main entire, clinically-focused details on ALS (Lou Gehrig's sickness) in print. the 3 authors, well known for his or her paintings during this region, offer cohesive and balanced assurance of this syndrome, together with the background, medical positive factors, pathology and pathogenesis, therapy and administration of ALS. To facilitate knowing, each one bankruptcy is improved through complete tables and figures, in addition to designated bankruptcy summaries.
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Amyotrophic Lateral Sclerosis offers the main finished, clinically-focused info on ALS (Lou Gehrig's sickness) in print. the 3 authors, widely recognized for his or her paintings during this sector, offer cohesive and balanced assurance of this syndrome, together with the background, medical beneficial properties, pathology and pathogenesis, remedy and administration of ALS.
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Progressive bulbar palsy, progressive spinal muscular atrophy) in reporting the epidemiology of motor neuron disease. Here, we will use the term ALS to encompass all these types of motor neuron degeneration because most cases eventually progress to become classic ALS. 84,110,131 True progressive bulbar palsy is rare and progressive spinal muscular atrophy is uncommon (see Chapter 1). 106 The terminology and definition of ALS are discussed in detail in Chapter 1. 12,20,92,105,107,155 Epidemiology DEFINITIONS AND CASE IDENTIFICATION IN ALS EPIDEMIOLOGY Definitions The frequency of ALS in the population can be represented by its incidence (the number of newly identified patients per year) or by its prevalence (the number of surviving patients at any given time).
Upper motor neuron signs such as the extensor plantar responses described later (in 1896) by Joseph Babinski,4 a famed student of Charcot, had not yet been appreciated. Disagreeing with Charcot, in 1870 Leyden 4 insisted that PBP and ALS were not distinct conditions. This opinion was based on his experience with patients with PBP in whom progressive atrophy developed in the small hand muscles. Autopsy examination in these patients disclosed white matter degeneration in areas corresponding to the corticospinal tracts.
12. Charcot, JM: De la sclerose laterale amyotrophique. Prog Med 23:235-237, 24:341-342, 1874; 29:453-455, 1874. 13. Charcot, JM: Lectures on the Diseases of the Nervous System. Sigerson, S (ed, trans). Hafner, New York, 1962. 14. Charcot, JM and Joffroy, A: Deux cas d'atrophie musculaire progressive. Arch Physiol 2:354—367, 1869. 15. Cruveilhier, J: Sur la paralysie musculaire progressive atrophique. Arch Gen Med 91:561-603, 1853. 16. Dejerine, J: Etude anatomique et clinique sur la paralysie labio-glosso-laryngee.
Amyotrophic Lateral Sclerosis by Hiroshi Mitsumoto MD